Project Example
Monoclonal Antibody Purification Process Optimization
Concuir’s consultants significantly improved the overall equipment effectiveness (OEE) of one client’s large scale monoclonal antibody purification process. We helped our client achieve these feats by addressing O-ring failures in the slurry nozzles, introducing variable height chromatography, and increasing the team’s proficiency in handling columns through training.
All the training we provided enabled our client’s in-house team to pack columns properly and efficiently in a repeatable manner, confidently test column packing quality, perform and interpret height equivalent to a theoretical plate (HETP) and asymmetry calculations, and enforce proper preventative maintenance procedures. The training not only aided in significantly improving OEE, but also reduced their in-house team’s column packing time by 70%, greatly enhancing team efficiency in production.
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More Project Examples by Concuir
100-Person FAT During COVID-19
A pharmaceutical manufacturing company came to Concuir with a predicament – they needed to coordinate and execute a factory acceptance test (FAT) for manufacturing equipment during a time when COVID-19 travel restrictions were ubiquitous.
Manufacturing Site Transfer and Analytical Method Optimization
A pharmaceutical client engaged Concuir to support a technology transfer of a solid oral dosage product from one contract manufacturer to another.
Redeveloped Existing CIP Cycles
In order to meet quality and validation requirements, Concuir assessed and subsequently redeveloped a client’s existing cleaning-in-place (CIP) cycle.